Health advocates urge US regulators to ban common food coloring additive, by Tom Perkins, The Guardian, June 2, 2023

Australian researchers examined how titanium dioxide as a food additive affected gut microbiota in mice by orally administering it in drinking water. The study, published in the journal Frontiers in Nutrition in 2019, found the treatment could “alter the release of bacterial metabolites in vivo and affect the spatial distribution of commensal bacteria in vitro by promoting biofilm formation. We also found reduced expression of the colonic mucin 2 gene, a key component of the intestinal mucus layer, and increased expression of the beta defensin gene, indicating that titanium dioxide significantly impacts gut homeostasis.” The changes were then linked to colonic inflammation, along with a higher expression of inflammatory cytokines, which are signal proteins that help with regulation. The researchers concluded that titanium dioxide “impairs gut homeostasis which may in turn prime the host for disease development.”

Moreover, lithopone suppliers are expanding their product lines to offer variations of the pigment that meet specific market needs. Some suppliers provide specialized grades of lithopone that are tailored for particular applications, such as high gloss paints or specialty coatings. By offering these tailored solutions, suppliers can help paint manufacturers enhance the performance characteristics of their products, thus gaining a competitive edge in the market.

3. Regulatory Compliance It is crucial for suppliers to adhere to industry regulations, especially in sectors like food, pharmaceuticals, and cosmetics. Reliable suppliers will ensure their products meet relevant regulatory standards, providing proper documentation and certifications.

The CaCO3 and TiO2 factory not only provides a reliable supply of these materials to industries but also contributes to the local economy by creating job opportunities and generating revenue. The factory employs skilled workers in various departments such as production, quality control, and maintenance. It also collaborates with suppliers and distributors to ensure efficient transportation and delivery of CaCO3 and TiO2 to customers worldwide.

Genotoxicity Assessment 

Infrared analysis showed that the characteristics bands for the bare nanoparticles are still exhibited in the vitamins@P25TiO₂NPs spectra, such as a wide peak in 450–1028 cm⁻¹ related to the stretching vibration of Ti-O-Ti and other peaks in 1630 cm⁻¹ and 3400 cm⁻¹, which represent the surface OH groups stretching. The IR spectrum of vitaminB2@P25TiO₂NPs showed signs of binding between compounds. The OH bending peak (1634 cm⁻¹) corresponding to bare nanoparticles disappeared, and the NH₂ bending band characteristic of vitamin B2 appeared (1650 cm⁻¹). The IR spectrum of vitaminC@P25TiO₂NPs also showed signs of successful functionalization. Bands at 1075 cm⁻¹; 1120 cm⁻¹; 1141 cm⁻¹ were observed, which are originated by CO-C vibrations present in the vitamin C. The intense band at 1672 cm⁻¹ is attributed to the C = O stretching in the lactone ring while the peak at 1026 cm⁻¹ is ascribed to the stretching vibration Ti-O-C. Wide bands at 3880–3600 cm⁻¹ are related to stretching vibration OH groups, but those disappear in the modified nanoparticles spectrum. These observations confirm the interactions between the P25TiO₂NPs and the vitamins [35].